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journal article·2025-10Open access

Supramolecular Assembly and Interfacial Hydration of Tandem Repeat Dipeptides on 2D Nanomaterials: Insights From 3D‐AFM Measurements and MD Simulations (Small 39/2025)

Ayhan Yurtsever, Fabio Priante, Linhao Sun, Marie Sugiyama, Kazuki Miyata, Keisuke Miyazawa, Sanhanut Kesornsit, Katsuhiro Maeda, Adam S. Foster, Yuhei Hayamizu, Mehmet Sarikaya, Takeshi Fukuma

Small· Volume 21· Issue 39
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Source abstract

Abstract

Bionanomaterials In article number 2501785, Ayhan Yurtsever, Linhao Sun, Yuhei Hayamizu, Takeshi Fukuma, and co-workers investigate Tyr-His (YH) dipeptide tandem repeats assembled on cleaved graphite and MoS2 substrates. The study reveals how 3D hydration shells govern peptide nanoarchitecture assembly, with molecular visualization showing peptides adopt fully extended, linear conformations aligned with specific crystallographic orientations. The lengths of assembled peptides match their unfolded states, including hydration layers.
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Research context

Nanomaterials

OpenAlex topics: Supramolecular Self-Assembly in Materials · Diatoms and Algae Research · Machine Learning in Materials Science

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Affiliations

Nano Life Science Institute (WPI‐NanoLSI) Kanazawa University Kakuma‐machi Kanazawa 920‐1192 Japan

Department of Applied Physics Aalto University Helsinki 00076 FI Finland

Department of Materials Science and Engineering School of Materials and Chemical Technology Institute of Science Tokyo Tokyo 152‐8550 Japan

Graduate School of Frontier Science Initiative Kanazawa University Kakuma‐machi Kanazawa 920‐1192 Japan

Graduate School of Natural Science and Technology Kanazawa University Kakuma‐machi Kanazawa 920‐1192 Japan

DMXi Dentomimetix, Inc. 3729 NE 194th Str. Seattle WA 98155 USA

References

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