The Extremely Low Mechanical Force Generated by Nano‐Pulling Induces Global Changes in the Microtubule Network, Nuclear Morphology, and Chromatin Transcription in Neurons (Small 38/2025)
Source abstract
Abstract
Axon Development Mechanical force is a powerful inducer of axon growth. In article number 2503011, Vittoria Raffa and co-workers demonstrate that force also exerts global effects extending to the nuclear level. Stretched neurons show a reorganization of the microtubule network in the soma, particularly around the nucleus, where perinuclear microtubules preferentially align perpendicularly to the nuclear envelope, leading to significant nuclear remodeling and widespread transcriptional activation.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Force Microscopy Techniques and Applications · Cellular Mechanics and Interactions
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Affiliations
Department of Biology University of Pisa Pisa 56126 Italy
Center for Materials Interfaces Istituto Italiano di Tecnologia Pontedera 56025 Italy
NEST Istituto Nanoscienze‐CNR and Scuola Normale Superiore Pisa Italy
Department of Surgical Medical and Molecular Pathology Critical Care Medicine University of Pisa Pisa Italy
Center for Instrument Sharing University of Pisa Pisa 56124 Italy
References
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