journal article·2025-08Open access

Synthesis of Hydrogel Microparticles from Ultra‐High‐Viscosity Pre‐Gel Solution by Combining Centrifugal Force and Ultrasonic Vibration (Small 34/2025)

Yuta Bando, Ryota Kawamae, Ru Konno, Hiroaki Onoe, Yoshiyuki Tagawa, Yuta Kurashina

Small· Volume 21· Issue 34

Abstract

Hydrogel Microparticles In article number 2412715, Yuta Kurashina and co-workers devised a novel microparticle synthesis device for obtaining hydrogel microparticles from ultra-high-viscosity pre-gel solution, previously impossible to synthesize. The schematic highlights that the combination of centrifugal force and ultrasonic vibration promoted the ejection of ultra-high-viscosity pre-gel solution in micro-sized particles. In this study, the demonstration of mixing heterogeneous hydrogels and loading live cells contributes to the application of hydrogel microparticles for drug discovery research and tissue formation in hydrogels.
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Research context

OpenAlex topics: Hydrogels: synthesis, properties, applications · Electrospun Nanofibers in Biomedical Applications

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Affiliations

Department of Mechanical Systems Engineering Faculty of Engineering Tokyo University of Agriculture and Technology 2‐24‐16, Naka‐cho Koganei‐shi Tokyo 184–8588 Japan

Department of Mechanical Engineering Faculty of Science and Technology Keio University 3‐14‐1 Hiyoshi Kohoku‐ku Yokohama 223–8522 Japan

Institute of Global Innovation Research Tokyo University of Agriculture and Technology 2‐24‐16, Naka‐cho Koganei Tokyo 184–8588 Japan

References

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