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journal article·2025-07Open access

Atomic Force Microscopy Reveals Differences In Mechanical Properties Linked To Cortical Structure In Mouse And Human Oocytes (Small 29/2025)

Rose Bulteau, Lucie Barbier, Guillaume Lamour, Yassir Lemseffer, Marie‐Hélène Verlhac, Nicolas Tessandier, Elsa Labrune, Martin Lenz, Marie‐Emilie Terret, Clément Campillo

Small· Volume 21· Issue 29
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Source abstract

Abstract

Cell Mechanical Properties In article number 2500221, Marie-Emilie Terret, Clément Campillo, and co-workers investigates the mechanical properties of mammalian oocytes using atomic force microscopy, and their relationship with the actin cortex structure, shown here in this confocal spinning disc image of a mouse oocyte cortex stained with an actin probe (SiR-Actin). It is shown that maternal age, a critical factor for fertility, affects mouse oocyte mechanics correlating with alterations in their cortex structure, and that the evolution of mechanical properties differs between human and mouse oocyte development, highlighting species-specific differences in cortex organization.
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Research context

OpenAlex topics: Cellular Mechanics and Interactions · Bone Tissue Engineering Materials · Bone fractures and treatments

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Affiliations

LAMBE Univ Evry CNRS Université Paris‐Saclay Évry‐Courcouronnes 91025 France

Center for Interdisciplinary Research in Biology (CIRB) Collège de France Université PSL CNRS INSERM Paris 75005 France

Hospices Civils de Lyon service de médecine de la reproduction et préservation de fertilité; Inserm U1208 SBRI Université Claude Bernard Lyon 1 faculté de médecine Laennec France

LPTMS CNRS Université Paris‐Sud Université Paris‐Saclay Orsay 91405 France

Institut Universitaire de France (IUF) Paris 75005 France

References

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