DataVXSmallPaper
journal article·2025-06Open access

Volumetric Nanodroplet‐Enhanced Ultrasound Surgery Combined with Immune Checkpoint Inhibition as a Cancer Therapy Platform (Small 23/2025)

Bar Glickstein, Mike Bismuth, Roni Gattegno, Tiran Bercovici, Oz Shaul, Ramona Aronovich, Galit Horn, Anat Globerson Levin, Yi Feng, Tali Ilovitsh

Small· Volume 21· Issue 23
Publisher pageOpen full text
Source abstract

Abstract

Cancer Therapy In article number 2411474, Tali Ilovitsh and co-workers combine nanodroplet-mediated ultrasound surgery with checkpoint inhibition to enhance immunotherapy. Systemically injected nanodroplets accumulate in the tumor and are activated into cavitating gas bubbles using ultrasound imaging. Subsequent low-frequency ultrasound implodes the vaporized nanodroplets, inducing tumor fractionation and creating a T-cell–inflamed microenvironment. This approach integrates mechanical disruption with immune activation, addressing key barriers in solid tumor treatment.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Hydrogen's biological and therapeutic effects · Ultrasound and Hyperthermia Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biomedical Engineering Tel Aviv University Tel Aviv 6997801 Israel

The Sagol School of Neuroscience Tel Aviv University Tel Aviv 6997801 Israel

School of Electrical Engineering Tel Aviv University Tel Aviv 6997801 Israel

Immunology and Advanced CAR‐T Cell Therapy Laboratory Research & Development Department Tel‐Aviv Sourasky Medical Center Tel Aviv University Tel Aviv 6423906 Israel

Dotan Center for Advanced Therapies Tel‐Aviv Sourasky Medical Center Tel Aviv University Tel Aviv 6423906 Israel

The Key Laboratory of Biomedical Information Engineering of the Ministry of Education Department of Biomedical Engineering School of Life Science and Technology Xi′an Jiaotong University Xi′an 710049 China

References

Reference metadata was not supplied for this record.