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journal article·2025-06Open access

Ultrasound Guided Local Delivery of Bioorthogonal PDL1 Degrader for Enhanced Immunotherapy (Small 23/2025)

Lantian Wang, Zhaoyou Liu, Panpan Ji, Jiao Ma, Ke Mou, Tian Zhou, Yuan Liang, Bin Zhang, Mengying Wei, Guodong Yang, Wenqi Sun, Li Gong, Lijun Yuan

Small· Volume 21· Issue 23
Publisher pageOpen full text
Source abstract

Abstract

Immunotherapy In article number 2405549, Wenqi Sun, Li Gong, Lijun Yuan, and co-workers have designed a nanodroplet for targeted PDL1 degradation in the tumor region. The nanodroplet is endowed with the capacities to accumulate in the ocean of tumor vessels and be visible by ultrasound, serving as a submarine. Moreover, ultrasound could launch the biorthogonal PD1 armed missiles on the “submarine”, and the missiles in turn lock onto PDL1 and destroy it to unleash anti-tumor immunity.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Photodynamic Therapy Research Studies · Ultrasound and Hyperthermia Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Ultrasound Medicine Tangdu Hospital Air Force Medical University Xinsi Road NO. 569th Xi'an 710038 P. R. China

Department of Digestive Surgery State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and Xijing Hospital of Digestive Diseases Air Force Medical University Xi'an 710032 P. R. China

Department of Pathology Helmholtz Sino‐German Research Laboratory for Cancer Tangdu Hospital Air Force Medical University Xinsi Road NO. 569th Xi'an 710038 P. R. China

State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and Department of Biochemistry and Molecular Biology Air Force Medical University Xi'an 710032 P. R. China

References

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