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journal article·2025-06Open access

Internalization and Cellular Fate of Protein Corona‐Coated Nanoparticles by Multimodal Multi‐Scale Microscopy (Small 22/2025)

Flávia E. Galdino, Renata S. Rabelo, Isabella Scarpa, Juliana S. Yoneda, Sílvio R. Consonni, Adriana F. Paes Leme, Andrew M. Smith, Maria Harkiolaki, Mateus B. Cardoso

Small· Volume 21· Issue 22
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Source abstract

Abstract

Nanoparticles In article number 2409065, Mateus B. Cardoso and co-workers explore the intracellular fate of silica nanoparticles using multimodal microscopy. Cryogenic X-ray nanotomography and correlative fluorescence imaging reveal detailed nanoparticle trajectories from internalization to perinuclear localization, highlighting vesicle migration and fusion. These findings deepen our understanding of nanoparticle-cell interactions, supporting advancements in nanomedicine and drug delivery applications.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Advanced Biosensing Techniques and Applications · Molecular Biology Techniques and Applications · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Brazilian Synchrotron Light Laboratory (LNLS) Brazilian Center for Research in Energy and Materials (CNPEM) Campinas São Paulo 13083‐970 Brazil

Institute of Chemistry University of Campinas (UNICAMP) Campinas São Paulo 13083‐970 Brazil

“Gleb Wataghin” Institute of Physics University of Campinas (UNICAMP) Campinas São Paulo 13083‐970 Brazil

Department of Biochemistry and Tissue Biology Institute of Biology University of Campinas (UNICAMP) Campinas São Paulo 13083‐970 Brazil

Brazilian Biosciences National Laboratory (LNBio) Brazilian Center for Research in Energy and Materials (CNPEM) Campinas São Paulo 13083‐970 Brazil

Department of Bioengineering and Department of Materials Science and Engineering University of Illinois Urbana‐Champaign Urbana IL 61801 USA

Diamond Light Source Harwell Science and Innovation Campus Didcot Oxfordshire OX11 0DE UK

References

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