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journal article·2025-05Open access

Tetrahedral Framework Nucleic Acid (tFNA)‐Loaded Metformin (Met) Modulates Cellular Pyroptosis and AMPK to Ameliorate Type II Diabetic Periodontitis (Small 20/2025)

Qi Han, Jiaqi Li, Hao Deng, Sirong Shi, Mi Zhou, Xiaoxiao Cai, Yu Chen, Yunfeng Lin

Small· Volume 21· Issue 20
Publisher pageOpen full text
Source abstract

Abstract

Diabetic Periodontitis In article number 2411740, Yu Chen, Yunfeng Lin, and co-workers proposed a tetrahedral framework nucleic acid -metformin complex (TMC) to regulate inflammation and metabolism, thereby inhibiting periodontal bone loss in type II diabetes patients. It was found that TMC inhibited the destruction of periodontal tissue and inflammation in macrophages by suppressing pyroptosis and regulating AMPK. By loading metformin onto tFNA, the cellular uptake efficiency of metformin was enhanced, significantly improving the efficacy of metformin alone.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Oral microbiology and periodontitis research · Inflammasome and immune disorders

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Affiliations

State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases Department of Oral Pathology West China Hospital of Stomatology Sichuan University Chengdu Sichuan 610041 China

State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu Sichuan 610041 China

Sichuan Provincial Engineering Research Center of Oral Biomaterials Chengdu Sichuan 610041 China

National Center for Translational Medicine Shanghai Jiao Tong University Shanghai 200240 China

References

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