Nano‐Phase Separation and Analyte Binding in Aptasensors Investigated by Nano‐IR Spectroscopy (Small 19/2025)

Biosensors Understanding the nanostructure of biosensors is crucial for their tailored design. In article number 2409369, Martin Rabe and co-workers report a nanospectroscopic study of the fabrication and application of a DNA-aptamer biosensor designed for variant-specific sensing of the SARS-CoV-2 spike protein. Structural details such as chemical identification of nanophases and single-molecule detection of sensor-bound analyte are reported, advancing our understanding of the nanomorphology of these sensors.