journal article·2025-05Open access

A Binary siRNA‐Loaded Tetrahedral DNA Nanobox for Synergetic Anti‐Aging Therapy (Small 18/2025)

Ziqi Yue, Yichen Yang, Lulingxiao Nie, Yuezhang Sun, Qi Wang, Yunfeng Lin, Yang Gao, Xiaoxiao Cai

Small· Volume 21· Issue 18

Abstract

Anti-Aging Therapy In article number 2408323, Yang Gao, Xiaoxiao Cai, and co-workers developed a functionalized senotherapeutic nanoplatform by constructing a tetrahedral DNA nanostructure-based siRNA delivery system. This work demonstrated the efficacy of dual-acting drugs in alleviating age-associated pathologies and highlighted the potential of tetrahedral DNA nanostructure for constructing co-delivery nanoplatforms in anti-aging drug delivery.
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Research context

OpenAlex topics: Advanced biosensing and bioanalysis techniques · Molecular Communication and Nanonetworks · Nanoplatforms for cancer theranostics

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Affiliations

State Key Laboratory of Oral Diseases National Center for Stomatology National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu Sichuan 610041 China

Sichuan Provincial Engineering Research Center of Oral Biomaterials Chengdu Sichuan 610041 China

National Center for Translational Medicine Shanghai Jiao Tong University Shanghai 200240 China

References

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