Dual‐Integrin‐Targeted Supramolecular Peptide Nanoarchitectonics for Enhanced Hepatic Delivery and Antifibrotic Therapy (Small 15/2025)
Source abstract
Abstract
Peptide Nanoarchitectonics A rationally designed self-assembling peptide, featuring dual integrin-binding motifs for α5β1 and αvβ3, forms nanoparticles capable of encapsulating rhein. The resulted peptide-rhein nanoarchitectonics exhibit improved hepatic delivery and enhanced antifibrotic therapeutic effects based on the combination of multiple targets and therapeutic modules, demonstrating a promising strategy for hepatic fibrosis therapy. More in article number 2409038, Yan Huang, Xuehai Yan, Qianli Zou, and co-workers.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: RNA Interference and Gene Delivery · Liver physiology and pathology · Nanoparticle-Based Drug Delivery
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Affiliations
School of Pharmacy Anhui Medical University Hefei 230032 China
State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 China
Institute of Health and Medicine Hefei Comprehensive National Science Center Hefei 230061 China
References
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