journal article·2025-04Open access

Microtubules Disruption Alters the Cellular Structures and Mechanics Depending on Underlying Chemical Cues (Small 13/2025)

Shimaa A. Abdellatef, Hongxin Wang, Jun Nakanishi

Small· Volume 21· Issue 13

Abstract

Microtubules Disruption The roles of microtubules (MT) in cellular and nuclear morphologies, as well as mechanical responses were studied on substrates with different cell-adhesive ligand (cRGD) density. In low cRGD density, MTs and actin stress fibers aligned in elongated cells, while tangled MTs and external actin bundles formed in rounded cells on high cRGD density. More in article number 2312282, Shimaa A. Abdellatef, Hongxin Wang, and Jun Nakanishi.
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Research context

OpenAlex topics: Cancer Research and Treatment

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Affiliations

Research Center for Macromolecules and Biomaterials National Institute for Materials Science (NIMS) 1‐1 Namiki Tsukuba 305‐0044 Japan

Graduate School of Advanced Engineering Tokyo University of Science 6‐3‐1, Niijuku Katsushika‐ku Tokyo 125‐8585 Japan

Graduate School of Advanced Science and Engineering Waseda University 3‐4‐1 Okubo Shinjuku‐ku Tokyo 169‐8555 Japan

References

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