Endocytic Uptake of Self‐Assembled Iridium(III) Nanoaggregates for Holistic Treatment of Metastatic 3D Triple‐Negative Breast Tumor Spheroids (Small 13/2025)

Breast Cancer Triple-negative breast cancer (TNBC) presents a formidable therapeutic challenge due to its aggressive phenotype and limited treatment strategies. In article number 2406809, Ritika Gautam Singh and co-workers examine self-assembled organometallic Ir(III) nanoaggregates, which display notable cellular permeability and photoreactivity. IrL1 demonstrates nanomolar-range cytotoxicity, inducing ferroptosis-mediated cell death in TNBC cells and significantly inhibiting tumor growth in immunocompromised NOD-SCID mice, indicating strong potential for clinical translation.