DataVXSmallPaper
journal article·2025-03Open access

Precise Methylation Detection of Tumor Suppressor Gene Promoters by Magnetic Enrichment and Nano Silver Adduct–Promoted Surface‐Enhanced Raman Scattering (Small 11/2025)

Shubham Singh, Yu‐Wei Lin, Wen‐Jyun Wang, Yu‐Cheng Chang, Yi‐Hsin Chien, Wei‐Peng Li

Small· Volume 21· Issue 11
Publisher pageOpen full text
Source abstract

Abstract

Methylation Detection The gene adduct-modified silver cluster enables specific labeling of the methylation site on the tumor suppressor promoter. This cutting-edge system utilizes gene-hybridizable nanobeads for magnetic enrichment, ensuring targeted and efficient gene sample preparation. Silver-promoted surface-enhanced Raman scattering amplifies the 5-methyl cytosine signal, while localized hot spots around methylated and unmethylated promoters ensure precise methylation detection. More in article number 2407517, Yi-Hsin Chien, Wei-Peng Li, and co-workers.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Epigenetics and DNA Methylation · MicroRNA in disease regulation

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Medicinal and Applied Chemistry Kaohsiung Medical University Kaohsiung 807 Taiwan

Department of Materials Science and Engineering Feng Chia University Taichung 407 Taiwan

Master's Program of Green Energy Science and Technology Feng Chia University Taichung 407 Taiwan

Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung 807 Taiwan

Department of Medical Research Kaohsiung Medical University Hospital Kaohsiung 807 Taiwan

Center of Applied Nanomedicine National Cheng Kung University Tainan 701 Taiwan

References

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