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journal article·2025-02Open access

Rational Design of Lipid Nanoparticles for Enhanced mRNA Vaccine Delivery via Machine Learning (Small 8/2025)

Seo‐Hyeon Bae, Hosam Choi, Jisun Lee, Min‐Ho Kang, Seong‐Ho Ahn, Yu‐Sun Lee, Huijeong Choi, Sohee Jo, Yeeun Lee, Hyo‐Jung Park, Seonghyun Lee, Subin Yoon, Gahyun Roh, Seongje Cho, Youngran Cho, Dahyeon Ha, Soo‐Yeon Lee, Eun‐Jin Choi, Ayoung Oh, Jungmin Kim, Sowon Lee, Jungmin Hong, Nakyung Lee, Minyoung Lee, Jungwon Park, Dong‐Hwa Jeong, Kiyoun Lee, Jae‐Hwan Nam

Small· Volume 21· Issue 8
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Source abstract

Abstract

Lipid Nanoparticles An innovative integration of artificial intelligence (AI) with in-vivo experiments of mRNA delivery and expression for optimizing the lipid nanoparticles (LNPs) structure. The AI-driven in-silico models, represented by AI mice, enabled the identification of key chemical structures guiding the selection of LNP candidates. We validated the efficacy of LNPs through in-vivo administration in experimental mice, confirming the predictions of our in-silico models. More in article number 2405618, Dong-Hwa Jeong, Kiyoun Lee, Jae-Hwan Nam, and co-workers.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: RNA Interference and Gene Delivery · SARS-CoV-2 and COVID-19 Research · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Medical and Biological Sciences The Catholic University of Korea Bucheon 14662 Republic of Korea

Department of Biotechnology The Catholic University of Korea Bucheon 14662 Republic of Korea

Department of Chemistry The Catholic University of Korea Bucheon 14662 Republic of Korea

Department of Biomedical‐Chemical Engineering The Catholic University of Korea Bucheon 14662 Republic of Korea

Department of Artificial Intelligence The Catholic University of Korea Bucheon 14662 Republic of Korea

School of Chemical and Biological Engineering Institute of Chemical Processes Seoul National University Seoul 08826 Republic of Korea

Center for Nanoparticle Research Institute of Basic Science (IBS) Seoul 08826 Republic of Korea

Institute of Engineering Research College of Engineering Seoul National University Seoul 08826 Republic of Korea

Advanced Institutes of Convergence Technology Seoul National University Suwon‐si 16229 Republic of Korea

SML Biopharm Gwangmyeong 14353 Republic of Korea

References

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