Pathogenic Mutation ΔK280 Promotes Hydrophobic Interactions Involving Microtubule‐Binding Domain and Enhances Liquid‐Liquid Phase Separation of Tau (Small 6/2025)
Source abstract
Abstract
Pathogenic Mutation ΔK280 In article number 2406429, Jinghui Luo, Guanghong Wei, and co-workers studied the effect of pathogenic mutation ΔK280 on the LLPS of tau K18 via multiscale simulations and experiments. Their results demonstrate that ΔK280 mutation can enhance K18 phase separation by promoting β-sheet formation and increasing the PHF6*-involved hydrophobic interactions.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Lanthanide and Transition Metal Complexes · Aquatic and Environmental Studies
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Affiliations
Department of Physics State Key Laboratory of Surface Physics, and Key Laboratory for Computational Physical Sciences (Ministry of Education) Fudan University Shanghai 200438 P. R. China
Department of Biology and Chemistry Paul Scherrer Institute Villigen 5232 Switzerland
Department of Physics and International Centre for Quantum and Molecular Structures College of Sciences Shanghai University Shanghai 200444 P. R. China
References
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