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journal article·2024-09Open access

The Next Generation COVID‐19 Antiviral; Niclosamide‐Based Inorganic Nanohybrid System Kills SARS‐CoV‐2 (Small 39/2024)

Goeun Choi, N. Sanoj Rejinold, Huiyan Piao, Young Bae Ryu, Hyung‐Jun Kwon, In Chul Lee, Jeong In Seo, Hye Hyun Yoo, Geun‐woo Jin, Jin‐Ho Choy

Small· Volume 20· Issue 39
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Source abstract

Abstract

COVID-19 Antiviral The global need for next generation antivirals due to SARS-CoV-2 mutations led to interest in niclosamide, a broad spectrum antiviral. XAFTY is a niclosamide-inorganic nanohybrid drug proven for its broad-spectrum antiviral activity, overcoming niclosamide's low bioavailability. It has been confirmed in animal models to reduce SARS-CoV-2 viral load and prevent infection-induced lung inflammation, and its safety was confirmed in the clinical trials. More in article number 2305148, Geun-woo Jin, Jin-Ho Choy, and co-workers.
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Research context

Nanomaterials

OpenAlex topics: Advanced Nanomaterials in Catalysis · Nanoplatforms for cancer theranostics

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Affiliations

Intelligent Nanohybrid Materials Laboratory (INML) Institute of Tissue Regeneration Engineering (ITREN) Dankook University Cheonan 31116 Republic of Korea

College of Science and Technology Dankook University Cheonan 31116 Republic of Korea

Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine Dankook University Cheonan 31116 Republic of Korea

Functional Biomaterials Research Center Korea Research Institute of Institute of Bioscience and Biotechnology (KRIBB) Jeongeup 34141 Republic of Korea

Institute of Pharmaceutical Science and Technology College of Pharmacy Hanyang University Ansan 15588 Republic of Korea

R&D Center CnPharm Co. LTD. Seoul 03759 Republic of Korea

Department of Pre‐Medical Course College of Medicine Dankook University Cheonan 31116 Republic of Korea

International Research Frontier Initiative (IRFI) Institute of Innovative Research Tokyo Institute of Technology Yokohama 226‐8503 Japan

References

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