Lysosome‐Targeting Bacterial Outer Membrane Vesicles for Tumor Specific Degradation of PD‐L1 (Small 43/2024)

Panpan Ji; Pengying Wu; Lantian Wang; Yufei Wang; Xin Guo; Ruiqi Gao; Zhiyu Guo; Haikun Zhou; Zhaoyou Liu; Yuan Liang; Fan Lu; Guodong Yang; Gang Ji

doi:10.1002/smll.202470319

journal article·2024-10Open access

Lysosome‐Targeting Bacterial Outer Membrane Vesicles for Tumor Specific Degradation of PD‐L1 (Small 43/2024)

Panpan Ji, Pengying Wu, Lantian Wang, Yufei Wang, Xin Guo, Ruiqi Gao, Zhiyu Guo, Haikun Zhou, Zhaoyou Liu, Yuan Liang, Fan Lu, Guodong Yang, Gang Ji

Small· Volume 20· Issue 43

Publisher page Open full text

Source abstract

Abstract

Tumor Therapy In article number 2400770, Fan Lu, Guodong Yang, Gang Ji, and co-workers developed an outer membrane vesicle (OMV)-based nanosystem to unleash the anti-tumor immunity via targeted degradation of PDL1. The tumor homing OMVs derived from engineered bacteria are empowered to trigger PDL1 degradation after simply absorbing dual ligands for lysosome-targeting receptor and PDL1. The proposed bacteria-driven PDL1 degrader is highly manufacturable and scalable, shedding new light on immune checkpoint blockade therapy.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Cancer Research and Treatments · Bacterial Infections and Vaccines

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Digestive Surgery State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and Xijing Hospital of Digestive Diseases Fourth Military Medical University Xi'an 710032 China

Department of Ultrasound Diagnostics Tangdu Hospital Fourth Military Medical University Xi'an 710038 China

State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and Department of Biochemistry and Molecular Biology Fourth Military Medical University Xi'an 710032 China

State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and Department of Biochemistry and Molecular Biology Military Medical Innovation Center Fourth Military Medical University Xi'an 710032 China

References

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