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journal article·2024-08Open access

Protein Aggregation on Metal Oxides Governs Catalytic Activity and Cellular Uptake (Small 34/2024)

Robert Nißler, Lena Dennebouy, Alexander Gogos, Lukas R.H. Gerken, Maximilian Dommke, Monika Zimmermann, Michael A. Pais, Anna L. Neuer, Martin T. Matter, Vera M. Kissling, Simone de Brot, Ioana Lese, Inge K. Herrmann

Small· Volume 20· Issue 34
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Source abstract

Abstract

Catalytically Active Nanomaterials Catalytically active nanomaterials offer significant potential for biomedical applications, including enhancing wound healing and inducing cancer cell death. In article number 2311115, Robert Nißler, Inge K. Herrmann, and co-workers demonstrate that protein corona formation reduces the catalytic efficacy of metal oxides and promotes their uptake by tissue-resident macrophages. Nonetheless, endosomal conditions partially restore the nanocatalytic activity and enable access to bioactivity.
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Research context

NanomaterialsCatalysis & surfaces

OpenAlex topics: Biological Research and Disease Studies · Cancer Research and Treatment · Folate and B Vitamins Research

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Affiliations

Nanoparticle Systems Engineering Laboratory, Institute of Energy and Process Engineering (IEPE), Department of Mechanical and Process Engineering (D‐MAVT) ETH Zurich Sonneggstrasse 3 Zurich 8092 Switzerland

Particles‐Biology Interactions, Department of Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa) Lerchenfeldstrasse 5 St. Gallen 9014 Switzerland

The Ingenuity Lab, University Hospital Balgrist University of Zurich Forchstrasse 340 Zurich 8008 Switzerland

Institute of Technical Chemistry and Environmental Chemistry Friedrich Schiller University Jena Philosophenweg 7a 07743 Jena Germany

Department of Plastic and Hand Surgery, Inselspital Bern University Hospital Bern 3010 Switzerland

COMPATH, Institute of Animal Pathology University of Bern Bern 3012 Switzerland

References

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