journal article·2024-08Open access

Cardiotoxicity Assessment through a Polymer‐Based Cantilever Platform: An Integrated Electro‐Mechanical Screening Approach (Small 33/2024)

Pooja P. Kanade, Nomin‐Erdene Oyunbaatar, Jongyun Kim, Bong‐Kee Lee, Eung‐Sam Kim, Dong‐Weon Lee

Small· Volume 20· Issue 33

Abstract

Cardiotoxicity Assessment In article number 2311274, Dong-Weon Lee and co-workers introduce a novel platform combining eight cantilevers with strain sensors and microelectrode arrays (MEA) for non-invasive, real-time monitoring of cardiomyocyte contraction force and field potential. It detects a minimum contraction force of 2 µN and MEA signals with a 50 µm diameter, accurately assessing cardiotoxicity profiles of various drugs, including those not affecting potassium channels.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Electrochemical sensors and biosensors · Conducting polymers and applications · Neuroscience and Neural Engineering

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Affiliations

School of Mechanical Engineering Chonnam National University Gwangju 61186 South Korea

Advanced Medical Device Research Center for Cardiovascular Disease Chonnam National University Gwangju 61186 Republic of Korea

Department of Biological Sciences Chonnam National University Gwangju 61186 Republic of Korea

Center for Next‐Generation Sensor Research and Development Chonnam National University Gwangju 61186 Republic of Korea

References

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