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journal article·2024-07Open access

Collagen Tubular Airway‐on‐Chip for Extended Epithelial Culture and Investigation of Ventilation Dynamics (Small 27/2024)

Wuyang Gao, Kayshani R. Kanagarajah, Emma Graham, Kayla Soon, Teodor Veres, Theo J. Moraes, Christine E. Bear, Ruud A. Veldhuizen, Amy P. Wong, Axel Günther

Small· Volume 20· Issue 27
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Source abstract

Abstract

Airway-on-a-Chip In article number 2309270, Axel Günther and co-workers present a collagen tube-based airway model with an epithelium that is perfused with warm, humid air while supplying from the outside culture medium and compensating for evaporation. The model recapitulates human small airways of a patient's lung, allowing for the first time to investigate the impact of different breathing and mechanical ventilation conditions on the epithelium to be investigated.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Tracheal and airway disorders

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Mechanical and Industrial Engineering University of Toronto 5 King's College Road Toronto Ontario M5S 3G8 Canada

Program in Developmental & Stem Cell Biology The Hospital for Sick Children 686 Bay Street PGCRL Research Tower Toronto Ontario M5G 0A4 Canada

Department of Laboratory Medicine and Pathobiology University of Toronto 1 King's College Circle Toronto Ontario M5S 1A8 Canada

Department of Physiology and Pharmacology University of Western Ontario 1151 Richmond St London Ontario N6A 3K7 Canada

Lawson Health Research Institute London Health Sciences Centre 750 Base Line Rd E London Ontario N6C 2R5 Canada

National Research Council Canada 75 Bd de Mortagne Boucherville Quebec J4B 6Y4 Canada

Department of Paediatrics University of Toronto 555 University Avenue Toronto Ontario M5G 1×8 Canada

Program in Molecular Medicine The Hospital for Sick Children 555 University Avenue Toronto Ontario M5G 1 × 8 Canada

Department of Physiology University of Toronto 1 King's College Circle Toronto Ontario M5S 1A8 Canada

Department of Biochemistry University of Toronto 1 King's College Circle Toronto Ontario M5S 1A8 Canada

Department of Medicine University of Western Ontario 1151 Richmond Street London Ontario N6A 5C1 Canada

Institute of Biomedical Engineering University of Toronto 164 College Street Toronto Ontario M5S 3G9 Canada

References

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