DataVXSmallPaper
journal article·2024-06

SSK1‐Loaded Neurotransmitter‐Derived Nanoparticles for Alzheimer's Disease Therapy via Clearance of Senescent Cells (Small 26/2024)

Wenbo Ji, Honglei Zhou, Wendanqi Liang, Weicong Zhang, Baofeng Gong, Tong Yin, Jianjian Chu, Jianhua Zhuang, Jian Zhang, Yi Luo, Yan Liu, Jie Gao, You Yin

Small· Volume 20· Issue 26
Publisher page
Source abstract

Abstract

Alzheimer's Disease Therapy SSK1-NPs efficiently delivered SSK1 into the brain, at where SSK1 is specifically cleaved by β-galactosidase, which in turn induces the apoptosis of senescent cells. Treatment of SSK1-NP induced apoptosis of senescence cells in the brain and improved cognitive function and memory in aged Alzheimer's disease mice. More in article number 2308574, Jian Zhang, Yi Luo, Yan Liu, Jie Gao, You Yin, and co-workers.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Graphene and Nanomaterials Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Neurology Second Afffliated Hospital (Shanghai Changzheng Hospital) of Naval Medical University Fengyang Road, Huangpu District Shanghai 200003 China

Department of General Surgery The First Affiliated Hospital with Nanjing Medical University Changle Road, Qinhuai District Nanjing 210006 China

School of Health Science and Engineering University of Shanghai for Science and Technology Jungong Road, Yangpu District Shanghai 200093 China

School of Pharmacy University College London Gower Street London W12 8LP UK

Department of Clinical Pharmacy Xinhua Hospital Shanghai Jiao Tong University School of Medicine Clinical Pharmacy Innovatton Instttute Shanghai Jiao Tong University School of Medicine Kongjiang Road, Yangpu District Shanghai 200092 China

New Drug Discovery and Development Biotheus Inc Keji 7th Road, TangjiawanTown Zhuhai 519080 China

Changhai Clinical Research Unit Shanghai Changhai Hospital Naval Medical University Changhai Road, Yangpu District Shanghai 200433 China

Department of Neurology Shanghai East Hospital School of Medicine Tongji University Jimo Road, Pudong New District Shanghai 200120 China

References

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