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journal article·2024-06Open access

pH‐Responsive, Self‐Assembled Ruthenium Nanodrug: Dual Impact on Lysosomes and DNA for Synergistic Chemotherapy and Immunogenic Cell Death (Small 24/2024)

Yu Lu, Di Zhu, Bo Hu, Rong Chen, Xin Wang, Xiaoxue Xu, Wenjing Wang, Hao Wu, Yuji Wang

Small· Volume 20· Issue 24
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Source abstract

Abstract

Nanodrugs An arginyl-glycyl-aspartic acid peptide-modified carboline ruthenium complex KS-Ru self-assembled in a pH-sensitive manner. It entered the lysosomes and formed nanoflowers, leading to lysosomal swelling. In addition, it entered the nucleus to damage DNA, inducing immunogenic cell death. Thus, it realized a dual impact on tumor growth and metastasis through synergistic chemotherapy and immunogenic cell death. More in article number 2310636, Yuji Wang and co-workers.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Advanced biosensing and bioanalysis techniques · RNA Interference and Gene Delivery · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Medicinal Chemistry College of Pharmaceutical Sciences of Capital Medical University Beijing 100069 P. R. China

Beijing Area Major Laboratory of Peptide and Small Molecular Drugs Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China Beijing Laboratory of Biomedical Materials Laboratory for Clinical Medicine Capital Medical University Beijing 100069 P. R. China

Department of Core Facility Center Capital Medical University Beijing 100069 P. R. China

Beijing Institute of Hepatology Beijing Youan Hospital Capital Medical University Beijing 100069 P. R. China

Xuanwu Hospital Capital Medical University Beijing 100053 P. R. China

References

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