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journal article·2024-05Open access

Selective Uptake Into Inflamed Human Intestinal Tissue and Immune Cell Targeting by Wormlike Polymer Micelles (Small 21/2024)

Elena Gardey, Zoltan Cseresnyes, Fabian H. Sobotta, Juliane Eberhardt, Drilon Haziri, Philip C. Grunert, Maren T. Kuchenbrod, Franka V. Gruschwitz, Stephanie Hoeppener, Michael Schumann, Nikolaus Gaßler, Marc T. Figge, Andreas Stallmach, Johannes C. Brendel

Small· Volume 20· Issue 21
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Source abstract

Abstract

Wormlike Polymer Micelles In article number 2306482, Andreas Stallmach, Johannes C. Brendel, and co-workers found that wormlike polymer micelles in contrast to spherical structures translocate selectively into inflamed intestinal mucosa without affecting healthy tissue. Entering the lamina propria, the micelles further passively target only immune cells of the inflamed biopsy, which is key for effective treatment of IBD and elimination of drug-related side effects.
Source: openalex_inverted_index · Quality: baseline

Research context

Polymers

OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics

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Affiliations

Department of Internal Medicine IV (Gastroenterology Hepatology Infectious Diseases and Central Endoscopy) Jena University Hospital Am Klinikum 1 07747 Jena Germany

Jena Center for Soft Matter (JCSM) Friedrich Schiller University Jena Philosophenweg 7 07743 Jena Germany

Applied Systems Biology Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute (HKI) Beutenbergstraße 11a 07745 Jena Germany

Laboratory of Organic and Macromolecular Chemistry (IOMC) Friedrich Schiller University Jena Humboldtstraße 10 07743 Jena Germany

Department of Chemical Engineering and Chemistry & Institute for Complex Molecular Systems Eindhoven University of Technology Eindhoven 5612 AZ the Netherlands

Department of Gastroenterology Infectious Diseases and Rheumatology Campus Benjamin Franklin Charité‐University Medicine Hindenburgdamm 30 12200 Berlin Germany

Jena University Hospital Section of Pathology Institute of Forensic Medicine Friedrich Schiller University Jena Am Klinikum 1 07747 Jena Germany

Institute of Microbiology Faculty of Biological Sciences Friedrich Schiller University Jena Neugasse 25 07743 Jena Germany

References

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