pH‐Dependent Lyotropic Liquid Crystalline Mesophase and Ionization Behavior of Phytantriol‐Based Ionizable Lipid Nanoparticles (Small 20/2024)
Source abstract
Abstract
Lipid Nanoparticles In article number 2309200, Haitao Yu, Calum J. Drummond, Jiali Zhai, and co-workers revealed the intriguing pH-sensitive, non-ordered to ordered lyotropic liquid crystalline mesophase transformation of lipid nanoparticles containing the COVID-19 mRNA vaccine ionizable lipids. Using high-throughput synchrotron small angle X-ray scattering, membrane fusogenic cubic and hexagonal phases are identified as the ionizable lipids acquire protonation during endosomal acidification, playing a pivotal role for mRNA endosomal escape.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Supramolecular Self-Assembly in Materials · Lipid Membrane Structure and Behavior
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Affiliations
School of Science STEM College RMIT University 124 La Trobe Street Melbourne Victoria 3000 Australia
SAXS/WAXS beamline, Australian Synchrotron ANSTO 800 Blackburn Rd Clayton Victoria 3168 Australia
Centre for Respiratory Science and Health School of Health and Biomedical Sciences RMIT University Melbourne Victoria 3000 Australia
References
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