Nanorheology and Nanoindentation Revealed a Softening and an Increased Viscous Fluidity of Adherent Mammalian Cells upon Increasing the Frequency (Small 6/2024)

Nanorheology In article number 2304884, Ricardo Garcia and co-workers show that nanorheology reveals that cells soften and fluidize upon increasing the frequency of a mechanical stimulus. The response to a time-dependent deformation might be interpreted as a competition between the cell surface and cytosol. At low frequencies, the viscoelastic response is dominated by interactions at the cell surface. At high frequencies, the response is dominated by the cytosol liquid-like properties.