Small, Dynamic Clusters of Tir‐Intimin Seed Actin Polymerization (Small 52/2023)
Source abstract
Abstract
Protein Nanocondensates In article number 2302580, Michael P. Sheetz, Linda J. Kenney, and co-workers reconstitute elements of the Escherichia coli (EPEC) actin pedestals using supported lipid bilayer patterns with intimin and cells expressing functional transfected intimin receptor (Tir). Single-particle superresolution imaging (sptPALM) reveals dynamic functional (pTyr-Tir) Tir nanoclusters (180 nm) that recruit Nck and NWASP. These protein nanoclusters are kinetically sustained through membrane and cytoplasmic exchanges and seed interconnected actin filament networks.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Monoclonal and Polyclonal Antibodies Research · Advanced Biosensing Techniques and Applications · Bacteriophages and microbial interactions
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Affiliations
Mechanobiology Institute National University of Singapore bukit timah 117411 Singapore
Department of Biochemistry and Molecular Biology University of Texas Medical Branch Galveston TX 77555 USA
References
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