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journal article·2023-11Open access

Positron Emission Tomography Studies of the Biodistribution, Translocation, and Fate of Poly Allyl Amine‐Based Carriers for Sirna Delivery by Systemic and Intratumoral Administration (Small 48/2023)

Cristina Simo, Cristian Salvador, Patrizia Andreozzi, Vanessa Gomez‐Vallejo, Gabriela Romero, Damien Dupin, Jordi Llop, Sergio E. Moya

Small· Volume 19· Issue 48
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Source abstract

Abstract

Positron Emission Tomography Polyplex nanoparticles are prepared by complexation of siRNA and polyamines aimed at gene therapy applications for cancer treatment. The radiolabeled polyplexes are injected intratumorally in lung tumor tissue, resulting in a high retention of the nanoparticles in the malignant tissue. More details can be found in article number 2304326 by Jordi Llop, Sergio E. Moya, and co-workers.
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Research context

Nanomaterials

OpenAlex topics: RNA Interference and Gene Delivery · Advanced biosensing and bioanalysis techniques · Radiopharmaceutical Chemistry and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Radiochemistry and Nuclear Imaging laboratory Center for Cooperative Research in Biomaterials (CIC biomaGUNE) Basque Research and Technology Alliance (BRTA) Paseo de Miramon 194 Donostia‐San Sebastián 20014 Spain

Soft Matter Nanotechnology Center for Cooperative Research in Biomaterials (CIC biomaGUNE) Basque Research and Technology Alliance (BRTA) Paseo de Miramon 194 Donostia‐San Sebastián 20014 Spain

Department of Radiology Washington University School of Medicine in St. Louis St. Louis MO 63110 USA

CIDETEC Basque Research and Technology Alliance (BRTA) Parque Científico y Tecnológico de Gipuzkoa Miramon Pasealekua, 196 Donostia‐San Sebastián 20014 Spain

Consorzio Sistemi a Grande Interfase Department of Chemistry ‘Ugo Schiff’ University of Florence Via della Lastruccia 3, FI Sesto Fiorentino 50019 Italy

Department of Biomedical Engineering and Chemical Engineering The University of Texas at San Antonio San Antonio TX 78249 USA

References

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