DataVXSmallPaper
journal article·2023-11Open access

Spider Silk Protein Forms Amyloid‐Like Nanofibrils through a Non‐Nucleation‐Dependent Polymerization Mechanism (Small 46/2023)

Xingmei Qi, Yu Wang, Hairui Yu, Ruifang Liu, Axel Leppert, Zihan Zheng, Xueying Zhong, Zhen Jin, Han Wang, Xiaoli Li, Xiuzhe Wang, Michael Landreh, Ludmilla A. Morozova‐Roche, Jan Johansson, Sidong Xiong, Igor Iashchishyn, Gefei Chen

Small· Volume 19· Issue 46
Publisher pageOpen full text
Source abstract

Abstract

Spider Silk Proteins Both spider silk protein and Alzheimer's disease associated amyloid-β peptide can assemble into silk-like fibers that consist of nanofibrils. Spider silk proteins' unique primary structures have evolved to allow functional amyloid-like properties and direct their fibrillization pathways to avoid formation of cytotoxic intermediates. More details can be found in article number 2304031 by Gefei Chen and co-workers.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: Silk-based biomaterials and applications · Studies on Chitinases and Chitosanases · Enzyme Production and Characterization

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

The Jiangsu Key Laboratory of Infection and Immunity Institutes of Biology and Medical Sciences Soochow University Suzhou 215123 China

Department of Biosciences and Nutrition Karolinska Institutet Huddinge 14157 Sweden

College of Wildlife and Protected Area Northeast Forestry University Harbin 150040 China

Department of Microbiology Tumor and Cell Biology Karolinska Institutet Solna 17165 Sweden

Department of Pharmacology Xi'an Jiaotong University Shaanxi 710061 China

School of Engineering Sciences in Chemistry Biotechnology and Health Department of Biomedical Engineering and Health Systems KTH Royal Institute of Technology Huddinge 14152 Sweden

Department of Pharmacology College of Pharmacy Chongqing Medical University Chongqing 400016 China

Department of Neurology Shanghai Sixth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200233 China

Department of Medical Biochemistry and Biophysics Umeå University Umeå 90187 Sweden

References

Reference metadata was not supplied for this record.