journal article·2023-10Open access

A Dual‐Targeting Liposome Enhances Triple‐Negative Breast Cancer Chemoimmunotherapy through Inducing Immunogenic Cell Death and Inhibiting STAT3 Activation (Small 40/2023)

Kaipei Luo, Lu Yang, Chunmei Yan, Yuxin Zhao, Qiuxia Li, Xing Liu, Long Xie, Qiang Sun, Xiaofang Li

Small· Volume 19· Issue 40

Abstract

Triple-Negative Breast Cancer Chemoimmunotherapy In article number 2302834, Kaipei Luo, Xiaofang Li, and co-workers develop a LyP-1 and chondroitin sulfate dual-modified liposome co-loading paclitaxel and cryptotanshinone. The liposome enhances cellular uptake via p32/CD44 dual receptor-mediated endocytosis, and achieves potent triple-negative breast cancer chemoimmunotherapy through inducing immunogenic cell death and inhibiting STAT3 activation.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Immune cells in cancer · Chemokine receptors and signaling

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Affiliations

State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy Chengdu University of Traditional Chinese Medicine Chengdu 611137 China

Innovative Institute of Chinese Medicine and Pharmacy Chengdu University of Traditional Chinese Medicine Chengdu 611137 China

Personalized Drug Therapy Key Laboratory of Sichuan Province Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu 610072 China

References

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