Xenon Difluoride Dry Etching for the Microfabrication of Solid Microneedles as a Potential Strategy in Transdermal Drug Delivery (Small 27/2023)

Solid Microneedles Despite the significance of microneedles for drug delivery, high-cost, limited-geometries, and complex fabrication are still hampering their expansion. Xenon difluoride (XeF2) dry etching precisely manufactures thousands of microneedles with tunable dimensions and geometries on a single patch. Confirming their penetration with skin models and numerical analyses, these microneedles hold significant potential for noninvasive, pain-free, and effective drug delivery studies. More details can be found in article number 2206510 by Fatih Inci and co-workers.