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journal article·2023-06Open access

PEGylated Manganese–Zinc Ferrite Nanocrystals Combined with Intratumoral Implantation of Micromagnets Enabled Synergetic Prostate Cancer Therapy via Ferroptotic and Immunogenic Cell Death (Small 22/2023)

Hui Wang, Yu Guan, Chun Li, Jia Chen, Shaoyu Yue, Jieying Qian, Bangshun Dai, Changqin Jiang, Chenghao Wen, Longping Wen, Chaozhao Liang, Yunjiao Zhang, Li Zhang

Small· Volume 19· Issue 22
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Source abstract

Abstract

Synergetic Prostate Cancer Therapies In article number 2207077, Li Zhang, Yunjiao Zhang, Chaozhao Liang, and co-workers propose intratumoral implantation of micromagnets to actively attract intravenously-injected magnetic PEGylated manganese-zinc ferrite nanocrystals (PMZFNs) from blood vessels into tumor tissue. PMZFNs exert relatively durable tumoricidal effects by inducing ferroptotic/immunogenic cell death, eventually achieving synergetic prostate cancer therapy. This study provides a new approach to overcoming the limitations of conventional anti-tumor therapies.
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Research context

NanomaterialsBiomaterials

OpenAlex topics: Ferroptosis and cancer prognosis

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Affiliations

Department of Urology the First Affiliated Hospital of Anhui Medical University Institute of Urology Anhui Medical University Anhui Province Key Laboratory of Genitourinary Diseases Anhui Medical University Hefei 230022 P. R. China

School of Medicine School of Biomedical Sciences and Engineering South China University of Technology Guangzhou 510006 P. R. China

National Engineering Research Center for Tissue Restoration and Reconstruction and Key Laboratory of Biomedical Engineering of Guangdong Province South China University of Technology Guangzhou 510006 P. R. China

References

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