DataVXSmallPaper
journal article·2023-05Open access

Biofilm Potentiates Cancer‐Promoting Effects of Tumor‐Associated Macrophages in a 3D Multi‐Faceted Tumor Model (Small 19/2023)

Yanlin Deng, Yatian Fu, Song Lin Chua, Bee Luan Khoo

Small· Volume 19· Issue 19
Publisher pageOpen full text
Source abstract

Abstract

3D Multi-Faceted Tumor Models In article number 2205904, Bee Luan Khoo and co-workers present a novel microfluidic tumor model, TAMPIEB, which integrates tumor-associated macrophages (TAMs) and bladder cancer cells to investigate the influence of bacterial distribution on immunomodulation in the tumor microenvironment in vivo. This research represents the first successful demonstration that biofilm-induced inflammatory conditions can trigger the transformation of TAMs from a pro-inflammatory to a pro-tumor state.
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Research context

OpenAlex topics: Immune cells in cancer · Nanoplatforms for cancer theranostics · Extracellular vesicles in disease

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Affiliations

Department of Biomedical Engineering City University of Hong Kong Kowloon 999077 Hong Kong

Hong Kong Center for Cerebro‐Cardiovascular Health Engineering (COCHE) Kowloon 999077 Hong Kong

Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Hong Kong SAR Kowloon 999077 China

State Key Laboratory of Chemical Biology and Drug Discovery The Hong Kong Polytechnic University Hong Kong SAR Kowloon 999077 China

Shenzhen Key Laboratory of Food Biological Safety Control Kowloon 999077 Hong Kong

Research Centre for Deep Space Explorations (RCDSE) The Hong Kong Polytechnic University Hong Kong SAR Kowloon 999077 China

Department of Precision Diagnostic and Therapeutic Technology City University of Hong Kong Shenzhen‐Futian Research Institute Shenzhen 518057 China

References

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