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journal article·2023-04Open access

High Throughput Confined Migration Microfluidic Device for Drug Screening (Small 16/2023)

Zihan Yang, Zhihang Zhou, Tongxu Si, Zhengdong Zhou, Li Zhou, Y. Rebecca Chin, Liang Zhang, Xinyuan Guan, Mengsu Yang

Small· Volume 19· Issue 16
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Source abstract

Abstract

Drug Screening In article number 2207194, Mengsu Yang and co-workers design a high throughput microfluidic chip that could achieve multi-function drug screening against collective migration of cancer cells under confined environment. Using this device, three new compounds that could significantly inhibit confined migration of cancer cells are found: MA-5, SB-705498 and diphenyleneiodonium chloride (DPI). These compounds target mitochondria, actin polymerization and cell viability, respectively.
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Research context

Polymers

OpenAlex topics: Innovative Microfluidic and Catalytic Techniques Innovation

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Affiliations

Department of Biomedical Sciences and Tung Biomedical Sciences Centre City University of Hong Kong 83 Tat Chee Avenue Kowloon Hong Kong SAR 999077 P. R. China

Department of Precision Diagnostic and Therapeutic Technology City University of Hong Kong Futian Research Institute Shenzhen Guangdong 518000 P. R. China

Department of Gastroenterology the Second Affiliated Hospital of Chongqing Medical University Chongqing 400010 P. R. China

Department of Clinical Oncology the University of Hong Kong Hong Kong Hong Kong SAR 999077 P. R. China

References

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