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journal article·2023-04Open access

Functionalized Fullerene for Inhibition of SARS‐CoV‐2 Variants (Small 15/2023)

Taylor M. Page, Chuanxiong Nie, Lenard Neander, Tatyana L. Povolotsky, Anil Kumar Sahoo, Philip Nickl, Julia M. Adler, Obida Bawadkji, Jörg Radnik, Katharina Achazi, Kai Ludwig, Daniel Lauster, Roland R. Netz, Jakob Trimpert, Benedikt Kaufer, Rainer Haag, Ievgen S. Donskyi

Small· Volume 19· Issue 15
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Source abstract

Abstract

Inhibition of SARS-CoV-2 Variants In the article number 2206154, Ievgen S. Donskyi and co-workers describe effective SARS-CoV-2 inhibitor. Low molecular weight polyglycerol sulfate works in tandem with a single hydrophobic fullerene to prevent the infection in vitro. Investigated through plaque reduction assays, microscale thermophoresis (MST) binding studies, and molecular dynamics (MD) simulations, fullerene appears to nestle in to a solvent accessible hydrophobic pocket on the S1 spike protein.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Fullerene Chemistry and Applications · Carbon Nanotubes in Composites · Graphene and Nanomaterials Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institut für Chemie und Biochemie Freie Universität Berlin Takustr. 3 14195 Berlin Germany

Physics Department Freie Universität Berlin Arnimallee 14 14195 Berlin Germany

Max Planck Institute of Colloids and Interfaces Am Mühlenberg 1 14476 Potsdam Germany

BAM – Federal Institute for Material Science and Testing Division of Surface Analysis and Interfacial Chemistry Unter den Eichen 44–46 12205 Berlin Germany

Institut für Virologie Freie Universität Berlin Robert‐von‐Ostertag‐Straße 7 14163 Berlin Germany

Tiermedizinischen Zentrum für Resistenzforschung (TZR) Freie Universität Berlin 14163 Berlin Germany

Forschungszentrum für Elektronenmikroskopie and Core Facility BioSupraMol Freie Universität Berlin Fabeckstraße 36A 14195 Berlin Germany

References

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