Cascade Delivery to Golgi Apparatus and On‐Site Formation of Subcellular Drug Reservoir for Cancer Metastasis Suppression (Small 11/2023)
Source abstract
Abstract
Cancer Metastasis Suppression In article number 2204747, Yuan Huang and co-workers develop a strategy that enhances the targetability and retention of nano-drug in Golgi apparatus (GA) for cancer metastasis suppression. Hybrid cell membrane-coated nanoparticles cascade to delivering cargo into GA, and in return, loaded-Monensin, an exocytosis inhibitor, blocks nano-drug exocytosis like steel net. With GA retention of nano-drug and GA dysfunction, this strategy suppresses metastasis initialization via multiple GA-related pathways.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery · Lipid Membrane Structure and Behavior
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Key Laboratory of Drug‐Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant‐Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology West China School of Pharmacy Sichuan University Chengdu 610041 P. R. China
References
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