Construction and Functionalization of a Clathrin Assembly for a Targeted Protein Delivery (Small 8/2023)

Targeted Protein Deliveries In article number 2204620, Hak-Sung Kim and co-workers develop a new type of protein self-assembly using human clathrin for a targeted protein delivery. A redesigned clathrin triskelion is dual-functionalized with functional biomolecules. The resulting clathrin assembly exhibits a significantly high avidity and an efficient delivery of a protein cargo into tumor cells.