DataVXSmallPaper
journal article·2023-01Open access

An Enzymatic Antibiotic Adjuvant Modulates the Infectious Microenvironment to Overcome Antimicrobial Resistance of Pathogens (Small 4/2023)

Min Wei, Jiahe Wu, Heng Sun, Bo Zhang, Xi Hu, Qiyue Wang, Bowen Li, Lilan Xu, Teng Ma, Jianqing Gao, Fangyuan Li, Daishun Ling

Small· Volume 19· Issue 4
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Source abstract

Abstract

Anti-Infection Therapies In article number 2205471, Jianqing Gao, Fangyuan Li, Daishun Ling, and co-workers report a silver-based enzymatic nanoadjuvant (EnzNA) by self-assembling silver nanoclusters that can modulate intracellular and extracellular infectious microenvironments with pH discrepancy to overcome antimicrobial resistance of pathogens. The EnzNA-mediated modulation of the infectious microenvironment can effectively re-sensitize methicillin-resistant Staphylococcus aureus (MRSA) to antibiotics by eradicating biofilm and inducing ribosomal dysfunction, providing a paradigm shift in combating the emergence and evolution of antimicrobial resistance.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanocluster Synthesis and Applications · Advanced Nanomaterials in Catalysis · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Pharmaceutics Hangzhou Institute of Innovative Medicine College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China

Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical Engineering National Center for Translational Medicine Shanghai Jiao Tong University Shanghai 200240 China

Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province Affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine Hangzhou 310006 China

WLA Laboratories Shanghai 201203 China

Department of Clinical Pharmacy The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China

Cancer Center of Zhejiang University Zhejiang University Hangzhou 310058 China

References

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