Biofunctional Nanodot Arrays in Living Cells Uncover Synergistic Co‐Condensation of Wnt Signalodroplets (Small 50/2022)
Source abstract
Abstract
Wnt Signalodroplets High-density arrays of biofunctionalized nanodots with diameters of 300 nm enable spatially controlled assembly of active Wnt signaling platforms in the plasma membrane. Massive parallelization at the single cell level uncovers receptor density-dependent co-condensation of cytosolic effector proteins, suggesting a digitalized transmembrane signaling controlled by liquid–liquid phase separation. More details can be found in article number 2203723 by Martin Steinhart, Jacob Piehler, Changjiang You, and co-workers.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Tissue Engineering and Regenerative Medicine
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Biology/Chemistry and Center for Cellular Nanoanalytics (CellNanOs) Osnabrück University 49076 Osnabrück Germany
Department of Molecular and Cellular Physiology Department of Structural Biology Howard Hughes Medical Institute Stanford University School of Medicine Stanford CA 94305 USA
Department of Biochemistry University of Zurich Winterthurerstr. 190 Zurich 8057 Switzerland
References
Reference metadata was not supplied for this record.