Nanoparticle‐Based Follistatin Messenger RNA Therapy for Reprogramming Metastatic Ovarian Cancer and Ameliorating Cancer‐Associated Cachexia (Small 44/2022)

Tetiana Korzun; Abraham S. Moses; Jeonghwan Kim; Siddharth Patel; Canan Schumann; Peter R. Levasseur; Parham Diba; Brennan Olson; Katia Graziella De Oliveira Rebola; Mason Norgard; Youngrong Park; Ananiya A. Demessie; Yulia Eygeris; Vladislav Grigoriev; Subisha Sundaram; Tanja Pejovic; Jonathan R. Brody; Olena R. Taratula; Xinxia Zhu; Gaurav Sahay; Daniel L. Marks; Oleh Taratula

doi:10.1002/smll.202270234

journal article·2022-11Open access

Nanoparticle‐Based Follistatin Messenger RNA Therapy for Reprogramming Metastatic Ovarian Cancer and Ameliorating Cancer‐Associated Cachexia (Small 44/2022)

Tetiana Korzun, Abraham S. Moses, Jeonghwan Kim, Siddharth Patel, Canan Schumann, Peter R. Levasseur, Parham Diba, Brennan Olson, Katia Graziella De Oliveira Rebola, Mason Norgard, Youngrong Park, Ananiya A. Demessie, Yulia Eygeris, Vladislav Grigoriev, Subisha Sundaram, Tanja Pejovic, Jonathan R. Brody, Olena R. Taratula, Xinxia Zhu, Gaurav Sahay, Daniel L. Marks, Oleh Taratula

Small· Volume 18· Issue 44

Publisher page Open full text

Source abstract

Abstract

Ovarian Cancer Treatment In article number 2204436 by Daniel L. Marks, Oleh Taratula, and co-workers, follistatin mRNA delivered by lipid nanoparticles targets ovarian cancer clusters dispersed in the peritoneal cavity of mice. When combined with platinum chemotherapy, the proposed treatment may allow complete cytoreduction, enhance resilience to the iatrogenic burden of chemotherapeutic intervention, increase overall survival, and minimize chemotherapy-induced muscular atrophy and cancer-associated cachexia.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Cancer, Hypoxia, and Metabolism · Cancer, Lipids, and Metabolism · Cancer Research and Treatments

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Pharmaceutical Sciences College of Pharmacy Oregon State University 2730 S Moody Avenue Portland OR 97201 USA

Department of Biomedical Engineering Oregon Health & Science University 3303 SW Bond Avenue Portland OR 97239 USA

Medical Scientist Training Program Oregon Health & Science University 3181 SW Sam Jackson Park Road Portland OR 97239 USA

Papé Family Pediatric Research Institute Oregon Health & Science University SW Sam Jackson Park Rd, Mail Code L481 Portland OR 97239 USA

Knight Cancer Institute Oregon Health & Science University 2720 S Moody Avenue Portland OR 97201 USA

Departments of Obstetrics and Gynecology and Pathology Oregon Health & Science University 3181 SW Sam Jackson Park Road Portland OR 97239 USA

Brenden‐Colson Center for Pancreatic Care Oregon Health & Science University 2730 S Moody Avenue Portland OR 97201 USA

References

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