DataVXSmallPaper
journal article·2022-10Open access

TfR Aptamer Enhanced Blood‐Brain Barrier Penetration of Biomimetic Nanocomplexes for Intracellular Transglutaminase 2 Imaging and Silencing in Glioma (Small 40/2022)

Juan Su, Zhipeng Yao, Zixuan Chen, Sisi Zhou, Zhi Wang, Hongping Xia, Songqin Liu, Yafeng Wu

Small· Volume 18· Issue 40
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Source abstract

Abstract

Brain Tumor Theranostics In article number 2203448, Hongping Xia, Songqin Liu, Yafeng Wu, and co-workers prepare dual blood–brain barrier (BBB) targeting biomimetic nanocomplexes (TMPsM) for simultaneous accurate diagnosis and effective treatment of glioma. The biomimetic outer shells endow them with enhanced BBB penetration and ensure the delivery of theranostic agents into brain tumor sites for single intracellular transglutaminase 2-triggered self-assembly aggregation-induced emission imaging and RNAi therapy.
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Research context

Nanomaterials

OpenAlex topics: Extracellular vesicles in disease

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Affiliations

Jiangsu Engineering Laboratory of Smart Carbon‐Rich Materials and Device Jiangsu Province Hi‐Tech Key Laboratory for Bio‐Medical Research State Key Laboratory of Bioelectronics School of Chemistry and Chemical Engineering Southeast University Nanjing 211189 China

The Translational Research Institute for Neurological Disorders Department of Neurosurgery of Wannan Medical College The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College) Wuhu 241001 China

Testing and Certification Wuxi Institute of Inspection Wuxi 214125 China

References

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