Engineering Bioactive M2 Macrophage‐Polarized, Anti‐inflammatory, miRNA‐Based Liposomes for Functional Muscle Repair: From Exosomal Mechanisms to Biomaterials (Small 34/2022)

Zhiwen Luo; Beijie Qi; Yaying Sun; Yisheng Chen; Jinrong Lin; Haocheng Qin; Ning Wang; Runjie Shi; Xiliang Shang; Shiyi Chen; Jiwu Chen

doi:10.1002/smll.202270180

journal article·2022-08Open access

Engineering Bioactive M2 Macrophage‐Polarized, Anti‐inflammatory, miRNA‐Based Liposomes for Functional Muscle Repair: From Exosomal Mechanisms to Biomaterials (Small 34/2022)

Zhiwen Luo, Beijie Qi, Yaying Sun, Yisheng Chen, Jinrong Lin, Haocheng Qin, Ning Wang, Runjie Shi, Xiliang Shang, Shiyi Chen, Jiwu Chen

Small· Volume 18· Issue 34

Publisher page Open full text

Source abstract

Abstract

Macrophage Polarization In article number 2201957, Xiliang Shang, Shiyi Chen, Jiwu Chen, and co-workers find that myoblast-derived exosomes modulate macrophage polarization and contribute to muscle fibrosis within the post-injury inflammatory environment, while the miRNA inhibitor-loaded liposomes brake the vicious circle, induce M2 polarization, relieve the inflammatory response, and promote the functional recovery of the injured muscle. The authors provide a strategy for treating muscle injury through designing an M2 polarization-enabling anti-inflammatory and miRNA-based bioactive material.

Source: openalex_inverted_index · Quality: baseline

Research context

Biomaterials

OpenAlex topics: Extracellular vesicles in disease · Graphene and Nanomaterials Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Sports Medicine Huashan Hospital Fudan University Shanghai 200040 P. R. China

Department of Rehabilitation Huashan Hospital Fudan University Shanghai 200433 P. R. China

Department of Ophthalmology Shanghai 9th People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200011 P. R. China

Department of Otorhinolaryngology Head and Neck Surgery Shanghai ninth people's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200011 P. R. China

Department of Sports Medicine Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai Jiao Tong University Shanghai 200080 P. R. China

References

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