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journal article·2022-08Open access

Rationally Designed Heptamethine Cyanine Photosensitizers that Amplify Tumor‐Specific Endoplasmic Reticulum Stress and Boost Antitumor Immunity (Small 34/2022)

Xie Huang, Mingquan Gao, Haiyan Xing, Zaizhi Du, Zifei Wu, Jing Liu, Tao Li, Jiang Cao, Xiaochao Yang, Rong Li, Weidong Wang, Junping Wang, Shenglin Luo

Small· Volume 18· Issue 34
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Source abstract

Abstract

Cancer Phototherapy The endoplasmic reticulum (ER) plays an important role in protein synthesis, processing and secretion. ER-targeting phototherapy significantly amplifies ER stress, promotes tumor antigen release, and elicits a robust immunogenic cell death. In article number 2202728 by Weidong Wang, Junping Wang, Shenglin Luo, and co-workers, a small molecular heptamethine cyanine photosensitizer with binitro-substituted benzenesulfonamide (ER-Cy-poNO2) is designed and synthesized for tumor photodynamic therapy/photothermal therapy/immunotherapy by targeting the ER.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Cancer Research and Treatments · Photodynamic Therapy Research Studies

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Affiliations

State Key Laboratory of Trauma Burns and Combined Injury Institute of Combined Injury Chongqing Engineering Research Center for Nanomedicine College of Preventive Medicine Third Military Medical University (Army Medical University) Chongqing 400038 China

School of Medicine University of Electronic Science and Technology of China Department of Radiation Oncology Sichuan Key Laboratory of Radiation Oncology Sichuan Cancer Hospital Chengdu 610041 China

Department of Pharmacy Daping Hospital Third Military Medical University (Army Medical University) Daping Chongqing 400042 China

School of Biomedical Engineering and Medical Imaging Third Military Medical University (Army Medical University) Chongqing 400038 China

References

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