Contents: (Small 27/2016)

Supramolecular dendrimers created from small amphiphilic dendrons are able to mimic covalently constructed high-generation dendrimers for siRNA delivery, as presented by S. Pricl, L. Peng, and co-workers on page 3667. An optimal balance between the hydrophobic alkyl chain length and the hydrophilic dendritic portion is crucial for self-assembly of these amphiphilic dendrons into micellar nanostructures, and critically impacts the effectiveness of siRNA delivery and functional gene silencing.