Contents: (Small 24/2014)

C. Yu and co-workers demonstrate silica vesicles with fi ne control over the entrance size in the siliceous walls (<3.9-34 nm). On page 5068, the entrance size is shown to be crucial for the loading and releasing of biomolecules. Silica vesicles with an optimal entrance size exhibit high loading capacity, sustained release, and superior delivery effi ciency of therapeutical proteins into cells, showing promising potential for biological and biomedical applications.