Contents: (Small 43/2016)

workers report an advanced Bio-NEMS (nanoelectromechanical system) device for high-throughput cell trapping and gene delivery on a silicon-nanochannel array chip.With a thin-film hydrodynamic approach, individual cells are precisely positioned on a nanochannel array where the molecules of well-controlled dose are delivered into each cells.The device shows potential for transfection of electrogenic cells, gene therapy, and living cell interrogation. Drug DeliveryOn page 5944, T. Zhang, D. Xing, and co-workers utilize upconversion luminescent materials to construct a new theranostic nanoprobe.This probe detects and images specific tumor-related mRNA and monitors target-triggered therapeutic drug release according to the mRNA expression level under near infrared (NIR) irradiation. Carbon NanotubesThe exocytosis and underlying mechanism of single-walled carbon nanotubes (SWCNTs) in macrophages is revealed by B. Wan, L.-H.Guo, and co-workers on page 5998.Exocytosis of SWCNTs is initiated by the activation of the P2X 7 receptor, which accounts for the lysosomal secretion pathway as a potential mechanism for cells to repel SWCNTs.The cover image shows microtubules providing orbits for the exocytosis of SWCNTs-containing lysosomes.