Contents: (Small 16/2013)

Drug DeliveryA light-operated vehicle for targeted intracellular drug delivery has been constructed by J. Ren, X. Qu, and co-workers using photosensitizer-incorporated G-quadruplex DNAcapped mesoporous silica nanoparticles.Upon light irradiation, the photosensitizer generates reactive oxygen species, causing the DNA capping to be cleaved and allowing the cargo (drugs) to be released.This platform, described in detail on page 2793, makes it possible to develop a drug-carrier system for a synergistic combination of chemotherapy and photodynamic therapy for the treatment of cancer with a high spatial/temporal control. Multicolor EmissionMulticolor-emitting hybrid microspheres of block copolymers (BCPs) and quantum dots (QDs) are fabricated by B. J. Kim and co-workers with their nanostructures controlled in all three dimensions.On page 2667, location control and separation of the QDs within the microspheres are achieved using supramolecular assemblies of BCP micelles.Through ratiometric control of site-isolated, different-colored QDs, a full-color display without undesired Förster resonance energy transfer between the QDs is achieved.