Nanophotonics Enable Targeted Photothermal Silencing of Nociceptor Neurons (Small 14/2022)
Source abstract
Abstract
Nociceptor Neuron Silencing In article number 2103364, Sebastien Talbot, Christos Boutopoulos, and co-workers report a nanotechnology-enabled strategy to silence subsets of unmodified nociceptor neurons. It uses laser stimulation of neurons targeted with gold nanoparticles to heat-activate TRPV1, turning this channel into a cell-specific entry port for silencing drugs that block neuropeptide release (i.e., communication with other cells). This work establishes a paradigm for interfering with deleterious neuro-immune interplays.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Photoreceptor and optogenetics research · Circadian rhythm and melatonin · Sleep and Wakefulness Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Département de Pharmacologie et Physiologie Université de Montréal Montréal QC H3C 3J7 Canada
Centre de Recherche Hôpital Maisonneuve‐Rosemont Montréal QC H1T 2M4 Canada
Département d'ophtalmologie Université de Montréal Montréal QC H3C 3J7 Canada
Institut de Génie Biomédical Université de Montréal Montréal QC H3C 3J7 Canada
References
Reference metadata was not supplied for this record.