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journal article·2021-09Open access

Novel Core–Shell Polyamine Phosphate Nanoparticles Self‐Assembled from PEGylated Poly(allylamine hydrochloride) with Low Toxicity and Increased In Vivo Circulation Time (Small 35/2021)

Patrizia Andreozzi, Cristina Simó, Paolo Moretti, Joaquin Martinez Porcel, Tanja Ursula Lüdtke, Maria de los Angeles Ramirez, Lorenza Tamberi, Marco Marradi, Heinz Amenitsch, Jordi Llop, Maria Grazia Ortore, Sergio Enrique Moya

Small· Volume 17· Issue 35
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Source abstract

Abstract

Polyamine Phosphate Nanoparticles In article number 2102211, Sergio Enrique Moya and co-workers present supramolecular polyamine phosphate nanoparticles (PANs) assembled from polyamines modified with polyethylene glycol (PEG) that vary size and charge depending on the number of PEG molecules per polyamine. PEGylated PANs with 10 PEG chains per polyamine display a core shell structure and show a longer circulation in vivo and reduced toxicological endpoints in vitro through the screening of positive charges by the PEG shell.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Graphene and Nanomaterials Applications · Supramolecular Self-Assembly in Materials · Dendrimers and Hyperbranched Polymers

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Soft Matter Nanotechnology Group CIC biomaGUNE Basque Research and Technology Alliance (BRTA) Paseo Miramón 182, San Sebastián Guipúzcoa 20014 Spain

Consorzio Sistemi a Grande Interfase Department of Chemistry ‘Ugo Schiff' University of Florence Via della Lastruccia 3, Sesto Fiorentino Florence 50019 Italy

Radiochemistry and Nuclear Imaging Group CIC biomaGUNE Basque Research and Tech‐nology Alliance (BRTA) Paseo Miramón 182, San Sebastián Guipúzcoa 20014 Spain

Dipartimento di Scienze della Vita e dell'Ambiente Università Politecnica delle Marche Via brecce bianche Ancona I‐60131 Italy

Instituto de Nanosistemas UNSAM CONICET Avenida 25 de Mayo 1021 San Martín Buenos Aires 1650 Argentina

Department of Chemistry ‘Ugo Schiff' University of Florence Via della Lastruccia 3/13, Sesto Fiorentino Florence 50019 Italy

Institute of Inorganic Chemistry Graz University of Technology Stremayergasse 9/V Graz 8010 Austria

Centro de Investigación Biomédica en Red – Enfermedades Respiratorias (CIBERES) Av. Monforte de Lemos, 3–5 Madrid 28029 Spain

References

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