journal article·2021-07Open access

Microfluidics: Stochastic and Age‐Dependent Proteostasis Decline Underlies Heterogeneity in Heat‐Shock Response Dynamics (Small 30/2021)

Nadia Vertti‐Quintero, Simon Berger, Xavier Casadevall i Solvas, Cyril Statzer, Jillian Annis, Peter Ruppen, Stavros Stavrakis, Collin Y. Ewald, Rudiyanto Gunawan, Andrew J. deMello

Small· Volume 17· Issue 30

Abstract

In article number 2102145, Collin Y. Ewald, Rudiyanto Gunawan, and co-workers highlight a microfluidic device used for sorting adult C. elegans populations—in a high-throughput manner—based on individual GFP expression. The heterogeneous dynamic heat-shock response, its relation to proteostasis, and how it can predict lifespan are thoroughly studied. Image credit: Mrs. Yujia Ma.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Genetics, Aging, and Longevity in Model Organisms

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Affiliations

Institute of Chemical and Bioengineering ETH Zurich Zurich 8093 Switzerland

Department of Biosystems KU Leuven Leuven B‐3001 Belgium

Institute of Translational Medicine ETH Zurich Schwerzenbach 8603 Switzerland

Department of Chemical and Biological Engineering University at Buffalo ‐ SUNY Buffalo NY 14260 USA

References

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